1/30/2024 0 Comments High intensityThe method thereby relies on "the anaerobic energy releasing system almost maximally". The very high level of intensity, the interval duration, and number of bouts distinguish it from aerobic (cardiovascular) activity, because the body significantly recruits anaerobic energy systems (although not completely to the exclusion of aerobic pathways). HIIT involves exercises performed in repeated quick bursts at maximum or near maximal effort with periods of rest or low activity between bouts. "We hope our work will stimulate further research into how exercise helps improve metabolic health in humans.High-intensity interval training ( HIIT) is a training protocol alternating short periods of intense or explosive anaerobic exercise with brief recovery periods until the point of exhaustion. "Using state-of-the-art proteomics technology, our study provides new information about how skeletal muscle adapts to exercise training, including the identification of novel exercise-regulated proteins and acetyl-sites," concludes co-corresponding author Atul Deshmukh, Associate Professor at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen. The work also suggests that exercise-induced changes in the regulation of proteins through acetylation may contribute to boosting metabolism. For example, the reduced calcium sensitivity may explain why it can be harder for muscle contraction to occur after an athlete becomes fatigued. The results confirm some well-known changes to skeletal muscle proteins that occur after exercise, as well as identify new ones. Additionally, they observed changes in the amount of proteins that reduce the skeletal muscle's calcium sensitivity, which is essential for muscle contractions. The team also identified increased acetylation of mitochondrial proteins and enzymes that are involved in the production of cellular energy. Their analyses showed an increase in the production of proteins used to build mitochondria, which produce energy in cells, and in proteins related to muscle contractions. They also examined changes relating to 1,263 lysine acetyl-sites on 464 acetylated proteins. Using a technique called mass spectrometry, the team analysed changes to the composition of 3,168 proteins in tissue samples collected from the participants' thighs before the study and after they completed the training. They repeated this pattern four to five times per workout. The men worked out three times per week, finishing four minutes of cycling at a target rate of more than 90% of their maximum heart rate followed by a two-minute rest. ![]() ![]() Acetylation occurs when a member of the small molecule group, acetyl, combines with other molecules, and can affect the behaviour of proteins.įor their study, the team recruited eight healthy, untrained male volunteers to complete five weeks of high-intensity cycling training. We wanted to understand how exercise alters the muscles' protein content and how it regulates the activity of these proteins through a chemical reaction called acetylation," says first and co-corresponding author Morten Hostrup, Associate Professor at the Department of Nutrition, Exercise, and Sports at the University of Copenhagen, Denmark. "Exercising has many beneficial effects that can help prevent and treat metabolic diseases, and this is likely the result of changes in energy use by skeletal muscles. These results may explain the beneficial effects of HIIT on metabolism and pave the way for additional studies exploring how exercise impacts these processes. The findings suggest that HIIT boosts the amount of proteins in skeletal muscle that are essential for energy metabolism and muscle contraction, and chemically alters key metabolic proteins.
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